Tolerance happens when the brain adapts over time and the same dose feels weaker.
For adults 50+, the biggest risks are inconsistency and accidental overuse when restarting too quickly.
Why tolerance changes
- The endocannabinoid system can down-regulate with frequent stimulation.
- Sleep quality, stress, and dehydration can make perceived effects change.
- Mixing with sedatives or alcohol may exaggerate side effects.
When a break may help
A structured break may be useful if:
- the same dose stopped giving expected effects,
- daytime grogginess increased,
- tolerance made side effects unpredictable.
If symptoms or chronic use concerns are significant, involve a clinician before changing use.
Safe return plan
- Choose a short break window you can complete.
- Keep a simple log (sleep, anxiety, pain, appetite).
- Restart with a reduced dose.
- Recheck every 2-3 hours if using edibles.
- Revisit blood pressure and sleep quality after two weeks.
Important limits
Do not combine a tolerance break plan with abrupt medication changes unless your clinician is aware. If you are using cannabis as part of symptom care, coordinate with the prescriber who oversees your condition.